Unusually Detected Anti-M Antibody Presenting as Cross Match Incompatibility in a Female Child Diagnosed with Small Round Cell Tumour
Published: May 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/25591.9862
Sheetal Anand Chandak, Aruna Vishwanath Vanikar
1. Assistant Professor, Department of Immunohaematology and Transfusion Sciences, Institute of Kidney Diseases and Transplantation Sciences, Ahmedabad, Gujarat, India.
2. Professor and Head, Department of Cell Therapy and Regenerative Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Ahmedabad, Gujarat, India.
Correspondence
Dr. Sheetal Anand Chandak,
A 401, Sankalp Sandipani Opp Gandhi Ashram Near Chandan Khadi Bhandar Subhash Bridge,
Ahmedabad-300026, Gujarat, India.
E-mail: sheetalchandak29@gmail.com
MNS antigen system is one of the human blood group systems. Anti-M antibody is a relatively common, naturally occurring antibody of IgM variety. Clinically significant anti-M antibody is reactive at 37°C in the anti-human globulin phase due to high thermal amplitude of IgM component or presence of IgG component. If anti-M antibody is activated at 37°C or in the anti-human globulin phase, it may cause delayed haemolytic transfusion reactions or haemolytic disease of newborn, which suggest variable clinical significance. We report a case of an unusually detected anti-M antibody presenting as cross match incompatibility in a one-year-old female child with a lump in the right lumbar region, which was later diagnosed as small round cell tumour in the right kidney.
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